Preheat your oven to 350 °F (175 °C). Grease a loaf pan (or line a baking sheet with foil if you prefer).
In a large bowl, combine the stuffing mix and water. Let it sit briefly until the stuffing absorbs the water and softens slightly.
Add the ground beef, eggs, and half of the ketchup to the softened stuffing mixture. Mix gently and just until everything is combined — avoid overmixing.
Press the mixture into the prepared loaf pan (or shape into a loaf and place on a lined baking sheet).
Spread the remaining ketchup evenly on top of the loaf.
Bake for about 45–50 minutes (or until the inside is cooked through — roughly 160 °F / 71 °C internal temperature).
Once out of the oven, let the meatloaf rest for 5–10 minutes before slicing. This helps the loaf stay moist and slice cleanly.