Heat a non-stick skillet over medium heat and lightly grease with olive oil or butter

Place one low-carb tortilla in the skillet and let it warm slightly

Spread a thin layer of pizza sauce evenly across the tortilla

Sprinkle half of the mozzarella cheese over the sauce

Add pepperoni slices evenly across the surface

Sprinkle Italian seasoning and garlic powder over the toppings

Add the remaining cheese on top to help seal the quesadilla

Place the second tortilla on top and press gently

Cook until the bottom is golden brown and crispy, then carefully flip

Cook the other side until the cheese is fully melted and both sides are crisp

Remove from heat, let it cool slightly, then slice into wedges and serve